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KMID : 0043319970200040372
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Archives of Pharmacal Research
1997 Volume.20 No. 4 p.372 ~ p.374
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Topical Anti-inflammatory Activity of Dianemycin Isolated from Streptomyces sp. MT 2705-4
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Lee Song-Jin
Kim Hyun-Pyo
Park Byung-Keun
Ahn Soon-Cheol
Lee Hyun-Sun
Ahn Jong-Seog
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Abstract
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In order to develop new anti-inflammatory agents having different action mechanisms compared with nonsteroidal and steroidal anti-inflammatory drugs, the culture broths of various actinomycetes isolated from soil were screened using an in vivo mouse ear edma assay and one strain (Streptomyces sp. MT 2705-4: KCTC 8651 P) was selected. Activity-guided purification led to the isolation of a polyether compound, dianemycin. Topically, dianemycin showed a potent anti-inflammatory activity in mouse ear edema induced by croton-oil or arachidonic acid.value of dianemycin was found to be 0.8 mg,/ear compared to 0.4 mg/ear of prednisolone in croton-oil ear edema. However, dianemycin did not show the inhibitory activity in UV-erythema and delayed hypersensitivity reaction. These results indicate that dianemycin is a potential topical anti-inflammatory agent.
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KEYWORD
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Dianemycin, Streptomyces, Topical, Anti-inflammatory activityl Ear edema, UV-erythema, Delayed hypersensititivity
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